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BioXCell熱銷(xiāo)產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152)

2023-09-01
瀏覽次數: 260

BioXCell熱銷(xiāo)產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152)

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產(chǎn)品描述:

9D9-CP006單克隆抗體是原始9D9單克隆抗體的重組嵌合型抗體??勺兘Y構域序列與原始9D9克隆號相同,但是恒定區序列已經(jīng)從小鼠IgG2b變?yōu)樾∈驣gG1。9D9-CP006單克隆抗體能與小鼠CTLA-4(細胞毒性T淋巴細胞抗原-4)反應,CTLA-4也稱(chēng)為CD152。CTLA-4是一種33 kDa的細胞表面受體,由屬于免疫球蛋白超家族CD28家族的Ctla4基因編碼。CTLA-4在活化的T淋巴細胞和B淋巴細胞上表達。CTLA-4在結構上類(lèi)似于T細胞共刺激蛋白CD28,兩種分子都與B7家族成員B7-1 (CD80)和B7-2 (CD86)結合。在與配體結合時(shí),CTLA-4負調節細胞介導的免疫反應。CTLA-4在誘導和/或維持免疫耐受、胸腺細胞發(fā)育和保護性免疫調節中起作用。CTLA-4在免疫下調中的關(guān)鍵作用已經(jīng)在CTLA-4缺陷小鼠中得到證實(shí),這些小鼠在3-5周齡時(shí)由于淋巴增生性疾病的發(fā)展而死亡。CTLA-4是目前腫瘤免疫檢查點(diǎn)治療的熱門(mén)靶點(diǎn)之一。

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產(chǎn)品詳情:

產(chǎn)品名稱(chēng)

RecombiMAb anti-mouse CTLA-4 (CD152)

產(chǎn)品貨號

CP006

產(chǎn)品規格

1mg

反應種屬

Mouse

克隆號

9D9-CP006

同種型

Mouse IgG1(switched from mouse IgG2b)

免疫原

Not available or unknown

實(shí)驗應用

in vivo CTLA-4 neutralization*

Western blot*

*Reported for the original mouse IgG2b 9D9 antibody

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無(wú)菌處理

0.2 μm filtration

純化方式

Protein G

分子量

150 kDa

小鼠病原檢測

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C,不能冷凍保存。

推薦同型對照

InVivoPlus mouse IgG1 isotype control, unknown specificity(貨號BP0083)

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer(貨號IP0070)

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該產(chǎn)品自上市已被多篇SCI文獻引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻引用:

應用

文章

體內CTLA-4中和

(in vivo CTLA-4?

neutralization)

1.?Dai, M., et al. (2015). 'Curing mice with large tumors by locally delivering?

combinations of immunomodulatory antibodies' Clin Cancer Res 21(5): 1127-1138.

2.?Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates acquired?

resistance to agonistic anti-CD40 treatment' Cancer Immunol Res 3(3): 236-244.

3.?Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory (OX40)?

and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of?

driving robust antitumor immunity' Cancer Immunol Res 2(2): 142-153.

4.?Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived suppressor?

cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 124(6): 2626-2639.

5.?Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in antibody-drug?

conjugates induce antitumor immunity by stimulation of dendritic cells' Cancer Immunol?

Res 2(8): 741-755.

6.?Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute to the antitumor?

activities of immunoregulatory receptor-targeting antibodies' J Exp Med 210(9): 1685-1693.

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BioXCell熱銷(xiāo)產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152)

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