BioXCell的中和/阻斷抗體受到國內外研究者的普遍熱愛(ài)和青睞,在腫瘤、癌癥等方面的研究中廣受好評。BioXCell公司位于美國新罕布什爾州,具有25年以上單克隆抗體和重組蛋白的生產(chǎn)及定制經(jīng)驗,可提供高純度、低內毒素、無(wú)防腐劑、適用于體內臨床前研究的單克隆抗體。
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| 高純度、低內毒素,無(wú)防腐劑,適用于體內臨床前研究 |
超過(guò)二十五年單克隆抗體和重組蛋白生產(chǎn)及定制經(jīng)驗 |
性?xún)r(jià)比高,可提供100mg甚至50g的大包裝 |
超過(guò)15000篇高質(zhì)量期刊文獻引用 |
腫瘤癌癥免疫治療應用?
●抑制免疫檢查點(diǎn)和其他免疫調節來(lái)治療惡性腫瘤是現在利用免疫系統殺死腫瘤細胞的有力途徑。BioXCell提供三種不同克隆號的anti?mouse PD-1抗體:RMP1-14、29F.1A12和J43。三種抗體都通過(guò)相同的機制發(fā)揮作用—它們結合PD-1,并在空間上阻斷PD-1與PD-1配體的結合,從而阻斷PD-1信號傳導。這三種克隆號的抗體都非常適合在小鼠體內模型中阻斷PD-1信號傳導,并有大量文獻支持這一應用。這些抗體之間的差異在于文獻報道中的其他應用、Isotype和來(lái)源。
●通過(guò)用阻斷PD-L1和它的受體PD-1之間的相互作用的抗體治療,腫瘤生長(cháng)可以暫時(shí)被抑制。
●抗PD-1聯(lián)合抗CTLA-4抗體介導的免疫治療對黑色素瘤、腎細胞癌和非小細胞肺癌具有顯著(zhù)療效。
●通過(guò)靶向調節免疫反應的途徑,如RANK途徑,可以將“cold”腫瘤轉化為“hot”腫瘤。使用Bio X Cell’s Anti-mouse RANKL (clone IK22/5) antibody,研究人員證明了對RANK通路的抑制將“cold”乳腺腫瘤轉化為“hot”腫瘤,變?yōu)椤癶ot”的腫瘤可能受益于免疫療法。
腫瘤研究相關(guān)的抗體
抗體指標 | 應用 | 克隆號 | InVivoMab | InVivoPlus | 同型對照 | 稀釋液 |
Anti mouse PD-1(CD279) | In vivo blocking of PD-1/PD-L signaling | RMP1-14 | BE0146 | BP0146 | BE0089 | IP0070 |
In vivo blocking of PD-1/PD-L signaling In vitro PD-1 neutralization IHC-Fr/Immunofluorescence/WB/FC | 29F.1A12 | BE0273 | BP0273 | BE0089 | IP0070 |
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In vivo blocking of PD-1/PD-L signaling In vitro PD-1 neutralization WB | J43 | BE0033-2 | BP0033-2 | BE0091 | IP0065 |
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Anti mouse PD-L1(B7-H1) | In vivo PD-L1 blockade IHC-Fr/Immunofluorescence/WB/FC | 10F.9G2 | BE0101 | BP0101 | BE0090 | IP0065 |
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Anti mouse CTLA-4 (CD152) | In vivo CTLA-4 neutralization WB | 9D9 | BE0164 | BP0164 | BE0086 | IP0070 |
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In vivo CTLA-4 neutralization In vitro CTLA-4 neutralization WB | 9H10 | BE0131 | BP0131 | BE0087 | IP0070 |
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In vivo CTLA-4 neutralization In vitro CTLA-4 neutralization WB/FC | UC10-4F10-11 | BE0032 | BP0032 | BE0091 | IP0065 |
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Anti mouse CD4 | In vivo CD4+ T cell depletion WB/FC | GK1.5 | BE0003-1 | BP0003-1 | BE0090 | IP0065 |
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Anti mouse CD8α | In vivo CD8+ T cell depletion Immunofluorescence/WB/FC | 53-6.7 | BE0004-1 | BP0004-1 | BE0089 | IP0065 |
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In vivo CD8+ T cell depletion WB | 2.43 | BE0061 | BP0061 | BE0090 | IP0070 |
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In vivo CD8+ T cell depletion WB | YTS 169.4 | BE0117 | BP0117 | BE0090 | IP0070 |
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Anti mouse Ly6G | In vivo neutrophil depletion In vivo MDSC depletion IHC-P/IHC-Fr/IF/FC | 1A8 | BE0075-1 | BP0075-1 | BE0089 | IP0065 |
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Anti mouse Ly6G/Ly6C (Gr-1) | In vivo depletion of Gr-1+ myeloid cells IHC-P/IHC-Fr/FC | RB6-8C5 | BE0075 | BP0075 | BE0090 | IP0070 |
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Anti mouse IFNγ | In vivo IFN-γ neutralization In vitro IFN-γ neutralization ELISPOT/WB/FC | XMG1.2 | BE0055 | BP0055 | BE0088 | IPT080 |
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Anti mouse IFNAR-1 | In vivo IFNAR-1 blockade In vitro IFNAR-1 blockade WB | MAR1-5A3 | BE0241 | BP0241 | BE0083 | IP0070 |
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Anti-mouse/human/rat/monkey/hamster/ canine/bovine TGF-β | In vivo TGF-β neutralization In vitro TGF-β neutralization WB | 1D11.16.8 | BE0057 | BP0057 | BE0083 | IP0070 |
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Anti mouse CD28 | In vitro T cell stimulation/activation In vivo CD28 blockade | 37.51 | BE0015-1 | / | BE0087 | IPT060 |
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in vitro T cell stimulation/activation | PV-1 | BE0015-5 | / | BE0091 | IP0070 |
Anti mouse CD3ε | In vitro T cell stimulation/activation In vivo T cell depletion Immunofluorescence/WB/FC | 145-2C11 | BE0001-1 | BP0001-1 | BE0091 | IP0070 |
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Anti-human CD3 | In vitro T cell stimulation/activation In vivo T cell depletion in humanized mice Ex vivo T cell inhibition for xenografts FC | OKT-3 | BE0001-2 | / | BE0085 | IP0070 |
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Anti mouse CD40 | In vivo CD40 activation In vitro B cell stimulation/activation | FGK4.5/ FGK45 | BE0016-2 | BP0016-2 | BE0089 | IP0070 |
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Anti mouse CD154 (CD40L) | In vivo blocking of CD40/CD40L signaling In vitro blocking of CD40/CD40L signaling WB | MR-1 | BE0017-1 | BP0017-1 | BE0091 | IP0070 |
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Anti mouse CD25 (IL-2Rα) | In vivo regulatory T cell depletion FC | PC-61.5.3 | BE0012 | BP0012 | BE0088 | IP0070 |
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Anti mouse IL-4 | In vivo IL-4 neutralization In vitro IL-4 neutralization In vivo IL-4 receptor stimulation (as a complex with IL-4) FC/WB | 11B11 | BE0045 | BP0045 | BE0088 | IP0070 |
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Anti mouse NK1.1 | In vivo NK cell depletion FC | PK136 | BE0036 | BP0036 | BE0085 | IP0070 |
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Anti mouse CSF1R (CD115) | In vivo macrophage depletion In vitro CSF1R neutralization In vivo monocyte depletion FC/WB | AFS98 | BE0213 | BP0213 | BE0089 | IP0070 |
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Anti mouse CD25?(IL-2Rα) | In vivo?regulatory T cell depletion FC | PC-61.5.3 | BE0012 | BP0012 | BE0088 | IP0070 |
anti-mouse OX40 (CD134) | In vivo OX40 activation In vitro OX40 activation WB | OX-86 | BE0031 | BP0031 | BE0088 | IP0070 |
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暢銷(xiāo)同型對照抗體
同型對照 | InVivoMab | InVivoPlus |
| 目錄號 | 目錄號 |
Rat IgG2a Isotype control, FC | BE0089 | BP0089 |
Rat IgG2b Isotype control | BE0090 | BP0090 |
Mouse IgG1 Isotype control | BE0083 | BP0083 |
Rat IgG1 Isotype control | BE0088 | BP0088 |
Mouse IgG2a Isotype control | BE0085 | BP0085 |
Mouse IgG2b Isotype control | BE0086 | BP0086 |
Polyclonal Armenian Hamster IgG | BE0091 | BP0091 |
InVivoPlus? Vs InVivoMab?系列之間區別
| InVivoMab | InVivoPlus |
純度 | > 95% | > 95% |
蛋白完整性 | √ (verified via SDS-PAGE) | √ü(verified via SDS-PAGE) |
內毒素濃度 | < 2EU/mg | < 1EU/mg |
不含疊氮化物和載體蛋白 | √ | √ |
是否適用于體內研究 | √ | √ |
是否提供大包裝 | √ | √ |
是否經(jīng)WB, FC或ELISA驗證 |
| √ |
經(jīng)驗證蛋白聚集≤?5% |
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是否經(jīng)過(guò)鼠科病原體檢測 |
| √ |
產(chǎn)品貨號 | BE-開(kāi)頭 | BP-開(kāi)頭
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BioXCell的RecombiMAb系列抗體
BioXCell的RecombiMAb系列抗體是新開(kāi)發(fā)的重組單克隆抗體,具有與其傳統克隆號來(lái)源相同的抗原結合可變區,但IgG恒定區已從大鼠或倉鼠IgG變?yōu)樾∈蠡蛉薎gG。這意味著(zhù)對于小鼠模型或人源化小鼠模型的免疫原性降低。
RecombiMAb單克隆抗體
產(chǎn)品名稱(chēng) | 宿主 | 亞型 | 貨號 | 同型對照 | 稀釋液 | 應用 |
Anti-Mouse PD-1 (CD279) (D265A) | Mouse | IgG2a, Κ | CP151 | CP150 | IP0070 | in vivo blocking of PD-1/PD-L signaling |
Anti-Mouse CTLA-4 (CD152) | Mouse | IgG1, Κ | CP146 | BP0083 | IP0070 | In vivo CTLA-4 neutralization? In vitro CTLA-4 neutralization? WB |
Human IgG4 (S228P) Isotype Control, Anti-Hen Egg Lysozyme | Human | IgG4, Κ | CP147 | - | - | - |
Human IgG4 S228P L235E P329G (SPLEPG) Isotype Control, Anti-Hen Egg Lysozyme | Human | IgG4 | CP148 | - | - | - |
Human IgG1 (LALA-PG) Isotype Control, Anti-Hen Egg Lysozyme | Human | IgG1 | CP149 | - | - | - |
Mouse IgG2a (D265A) Isotype Control, Anti-Hen Egg Lysozyme | Mouse | IgG2a | CP150 | - | - | - |
BioXCell的重組融合蛋白
融合蛋白即通過(guò)將細胞表面受體的結合域與抗體的Fc部分結合而形成,這樣可以使得配體分子不會(huì )結合到內源性受體,從而阻斷受體信號的傳導。蛋白純度大于95%,內毒素水平超低,不含防腐劑、穩定劑和載體蛋白等試劑,專(zhuān)為體內研究而開(kāi)發(fā)。
貨號 | 產(chǎn)品名稱(chēng) | 貨號 | 產(chǎn)品名稱(chēng) | 規格 |
BE0099 | InVivoMAb recombinant CTLA-4-lg | BP0099 | InVivoPlus recombinant CTLA-4-Ig | 5mg,25mg,50mg,100mg |
BE0098 | InVivoMAb recombinant Flt-3L-lg | BE0148 | InVivoMAb recombinant Mouse Angiostatin-lg | 5mg,25mg,50mg,100mg |
BE0149 | InVivoMAb recombinant Mouse Endostatin-lg | - | - | 5mg,25mg,50mg,100mg |
產(chǎn)品示例(圖片):
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